Urusei Yatsura: Terror of Girly-Eyes Measles

Directed by Shigeto Makino

Ten gives Ataru an alien disease, the contagious "Girl Measles," (which makes the victim's eyes turn big and twinkly, like the eyes of young girls in much of manga and anime), and when Ataru's girl-hunting spreads the virus all over Tomobiki Town, chaos ensues!